Description
Defibrotide is a polydeoxyribonucleotide that regulates endothelial cell functions and has antithrombical effects in the arteries, veins and capillaries. Various studies have proved the protective effect of defibrotide in different tissue and organ models. The aim of this study is to increase the effects of defibrotide applied after a high-cholesterol diet on lipid peroxidation in tissue and blood samples, antioxidant enzymes, antioxidant thiol composition glutation and nitric oxide regulation, a vasoactive mediator.
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